Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy
Identifieur interne : 001521 ( Main/Exploration ); précédent : 001520; suivant : 001522Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy
Auteurs : N. J. Cordato ; A. J. Duggins ; G. M. Halliday ; J. G. L. Morris ; C. PantelisSource :
- Brain [ 0006-8950 ] ; 2005-06.
English descriptors
- KwdEn :
- BA = Brodmann area, FBI = Frontal Behavioural Inventory, H&Y = Hoehn and Yahr, MMSE = Mini-Mental State Examination, MNI = Montreal Neurological Institute, PSP = progressive supranuclear palsy, Parkinson's disease, UPDRS = Unified Parkinson's Disease Rating Scale, VBM = voxel-based morphometry, progressive supranuclear palsy, regional brain atrophy, voxel-based morphometry.
Abstract
Most cerebral imaging studies of patients with progressive supranuclear palsy (PSP) have noted subtle atrophy, although the full extent of atrophy and any correlates to clinical features have not been determined. We used voxel-based morphometry analysis of grey matter, white matter and CSF on MRI brain scans to map the statistical probability of regional tissue atrophy in 21 patients with PSP, 17 patients with Parkinson's disease and 23 controls. PSP and Parkinson's disease cohorts were selected to approximate the mid-stages of their respective disease courses. Where regions of significant tissue atrophy were identified in a disease group relative to controls, the probability of tissue loss within those regions was correlated with global indices of motor disability, and behavioural and cognitive disturbance for that disease group. Minimal regional atrophy was observed in Parkinson's disease. PSP could be distinguished from both controls and Parkinson's disease by symmetrical tissue loss in the frontal cortex (maximal in the orbitofrontal and medial frontal cortices), subcortical nuclei (midbrain, caudate and thalamic) as well as periventricular white matter. For PSP, motor deficits correlated with atrophy of the caudate and motor cingulate, while behavioural changes related to atrophy in the orbitofrontal cortex and midbrain. These data suggest that intrinsic neurodegeneration of specific subcortical nuclei and frontal cortical subregions together contribute to motor and behavioural disturbances in PSP and differentiate this disorder from Parkinson's disease within 2–4 years of symptom onset.
Url:
DOI: 10.1093/brain/awh508
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy</title>
<author><name sortKey="Cordato, N J" sort="Cordato, N J" uniqKey="Cordato N" first="N. J." last="Cordato">N. J. Cordato</name>
</author>
<author><name sortKey="Duggins, A J" sort="Duggins, A J" uniqKey="Duggins A" first="A. J." last="Duggins">A. J. Duggins</name>
</author>
<author><name sortKey="Halliday, G M" sort="Halliday, G M" uniqKey="Halliday G" first="G. M." last="Halliday">G. M. Halliday</name>
</author>
<author><name sortKey="Morris, J G L" sort="Morris, J G L" uniqKey="Morris J" first="J. G. L." last="Morris">J. G. L. Morris</name>
</author>
<author><name sortKey="Pantelis, C" sort="Pantelis, C" uniqKey="Pantelis C" first="C." last="Pantelis">C. Pantelis</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:E868C6D4DC20C1202A7860C573B92E468500942A</idno>
<date when="2005" year="2005">2005</date>
<idno type="doi">10.1093/brain/awh508</idno>
<idno type="url">https://api.istex.fr/document/E868C6D4DC20C1202A7860C573B92E468500942A/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">001438</idno>
<idno type="wicri:Area/Main/Curation">001222</idno>
<idno type="wicri:Area/Main/Exploration">001521</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy</title>
<author><name sortKey="Cordato, N J" sort="Cordato, N J" uniqKey="Cordato N" first="N. J." last="Cordato">N. J. Cordato</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Duggins, A J" sort="Duggins, A J" uniqKey="Duggins A" first="A. J." last="Duggins">A. J. Duggins</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Halliday, G M" sort="Halliday, G M" uniqKey="Halliday G" first="G. M." last="Halliday">G. M. Halliday</name>
<affiliation><wicri:noCountry code="subField">NSW and</wicri:noCountry>
</affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Morris, J G L" sort="Morris, J G L" uniqKey="Morris J" first="J. G. L." last="Morris">J. G. L. Morris</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pantelis, C" sort="Pantelis, C" uniqKey="Pantelis C" first="C." last="Pantelis">C. Pantelis</name>
<affiliation><wicri:noCountry code="subField">Victoria Australia</wicri:noCountry>
</affiliation>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain</title>
<title level="j" type="abbrev">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2005-06">2005-06</date>
<biblScope unit="volume">128</biblScope>
<biblScope unit="issue">6</biblScope>
<biblScope unit="page" from="1259">1259</biblScope>
<biblScope unit="page" to="1266">1266</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">E868C6D4DC20C1202A7860C573B92E468500942A</idno>
<idno type="DOI">10.1093/brain/awh508</idno>
<idno type="local">awh508</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BA = Brodmann area</term>
<term>FBI = Frontal Behavioural Inventory</term>
<term>H&Y = Hoehn and Yahr</term>
<term>MMSE = Mini-Mental State Examination</term>
<term>MNI = Montreal Neurological Institute</term>
<term>PSP = progressive supranuclear palsy</term>
<term>Parkinson's disease</term>
<term>UPDRS = Unified Parkinson's Disease Rating Scale</term>
<term>VBM = voxel-based morphometry</term>
<term>progressive supranuclear palsy</term>
<term>regional brain atrophy</term>
<term>voxel-based morphometry</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Most cerebral imaging studies of patients with progressive supranuclear palsy (PSP) have noted subtle atrophy, although the full extent of atrophy and any correlates to clinical features have not been determined. We used voxel-based morphometry analysis of grey matter, white matter and CSF on MRI brain scans to map the statistical probability of regional tissue atrophy in 21 patients with PSP, 17 patients with Parkinson's disease and 23 controls. PSP and Parkinson's disease cohorts were selected to approximate the mid-stages of their respective disease courses. Where regions of significant tissue atrophy were identified in a disease group relative to controls, the probability of tissue loss within those regions was correlated with global indices of motor disability, and behavioural and cognitive disturbance for that disease group. Minimal regional atrophy was observed in Parkinson's disease. PSP could be distinguished from both controls and Parkinson's disease by symmetrical tissue loss in the frontal cortex (maximal in the orbitofrontal and medial frontal cortices), subcortical nuclei (midbrain, caudate and thalamic) as well as periventricular white matter. For PSP, motor deficits correlated with atrophy of the caudate and motor cingulate, while behavioural changes related to atrophy in the orbitofrontal cortex and midbrain. These data suggest that intrinsic neurodegeneration of specific subcortical nuclei and frontal cortical subregions together contribute to motor and behavioural disturbances in PSP and differentiate this disorder from Parkinson's disease within 2–4 years of symptom onset.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Cordato, N J" sort="Cordato, N J" uniqKey="Cordato N" first="N. J." last="Cordato">N. J. Cordato</name>
<name sortKey="Duggins, A J" sort="Duggins, A J" uniqKey="Duggins A" first="A. J." last="Duggins">A. J. Duggins</name>
<name sortKey="Halliday, G M" sort="Halliday, G M" uniqKey="Halliday G" first="G. M." last="Halliday">G. M. Halliday</name>
<name sortKey="Morris, J G L" sort="Morris, J G L" uniqKey="Morris J" first="J. G. L." last="Morris">J. G. L. Morris</name>
<name sortKey="Pantelis, C" sort="Pantelis, C" uniqKey="Pantelis C" first="C." last="Pantelis">C. Pantelis</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001521 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001521 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:E868C6D4DC20C1202A7860C573B92E468500942A |texte= Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy }}
This area was generated with Dilib version V0.6.23. |